The Chromatography Forum

of Delaware Valley

The theme of this year’s virtual event is Advancing Chromatorgaphy in Industry . 

The event will take place over the lunchtime hour of 12:00 – 1:00 p.m. on April 13 - 15, 2021.

There is no cost for the event this year due to its virtual nature so this is a perfect time to enjoy the science being shared, as well as get an inside look at the CFDV, one of the longest running chromatography organizations in the country.

Day 1: April 13, 2021
 

11:45 am Event log-in opens
11:50 – 11:55 am Welcome message from CFDV
11:55 am – 12:00 pm Shimadzu presentation
12:00 – 12:30 pm “Analysis of Trace VOCs and Off-Odor Compounds in Plastics by TD-GC×GC/FID/TOFMS” Chris Siegler, Dow

12:30 – 1:00 pm “Application of two-dimensional liquid chromatography for addressing challenges in the analysis of agrochemicals” Rahul Patil, Corteva Agriscience

“Analysis of Trace VOCs and Off-Odor Compounds in Plastics by TD-GC×GC/FID/TOFMS”
Chris Siegler, Dow
Abstract: Over the last decade, consumer markets (e.g. automotive, paints & coatings and food & beverage packaging) have driven a reduction in the amount of volatile organic components (VOCs) in finished products. One specific area of interest today is the use of plastics, such as polyvinylidene chloride, polystyrene, polycarbonate, polyethylene terephthalate (PET), and polyethylene (PE) in food and beverage packaging. In addition to protecting the food or beverage, the packaging must not alter the taste or aroma of the food or beverage. Because the human nose is extremely sensitive (able to detect VOCs in the parts-per-billion to parts-per-trillion range in a solvent matrix), it is challenging to develop an analytical method to detect and identify VOCs at these very low concentration levels. Thus, the industry has relied upon the use of human sensory panels. The ability to identify the molecular structure and origin of VOCs has become more important with the desire to replace virgin plastics with post-consumer recycle (PCR) plastics in food and beverage packaging. This presentation will cover the development of a Thermal Desorption System with comprehensive 2D GC separation and Mass Spectral detection (TDS-GCxGC/FID/TOMS) for separation and identification of VOCs coupled with chemometric data analysis as a pre-screening tool for human sensory panel testing.

“Application of two-dimensional liquid chromatography for addressing challenges in the analysis of agrochemicals”
Rahul Patil, Corteva Agriscience
Abstract: One-dimensional liquid chromatography is often unable to separate complex mixtures or closely related groups of compounds. Two-dimensional liquid chromatography (2D-LC) offers higher peak capacity and improved selectivity making it a valuable tool for resolving complex separation problems. Herein, we demonstrate the advantages of coupling two single LC orthogonal separations to solve issues associated with the analysis of agrochemical products. The 2D-LC is a powerful tool for the interrogation of the peak purities during active ingredient method development. The second dimension of the 2D-LC can be used simply and effectively to do the solvent exchange for investigating LC analyses with MS incompatible phases. The 2D-LC in combination with the high resolution mass spectrometry, can be a potent tool for the identification of unknown impurities to resolve concerns faced at the manufacturing sites. Application of 2D-LC in the Hydrogen-Deuterium exchange mass spectrometry (H - D exchange MS) is an efficient technique for the structure elucidation of small molecules.