Meet The Speaker
About
Andrew Alpert
Andrew Alpert received a BS degree in chemistry from Yale (1973), an MS degree in biochemistry from the Univ. of Nebraska Medical Center, and a Ph.D. in biochemistry from Purdue Univ. (1980), where he developed materials for HPLC of proteins under Fred Regnier. After two post-doctoral fellowships at Baylor College of Medicine in Houston, he moved to Maryland and started PolyLC in 1985. The company’s objective is to make materials available to chemists and biochemists for life science separations. When no suitable methods existed for particular applications, the company has developed them. This has resulted in the following advances: 1) The introduction of HILIC as a general-purpose mode of chromatography (1990); 2) The introduction of SCX materials for use with RPC in two-dimensional fractionation of peptides (1988). This combination was applied by John Yates in 1999 when he introduced the current paradigm for bottom-up proteomics; 3) PolyCAT A, the first reproducible material for high-performance cation-exchange HPLC of proteins. This is widely used for analysis of hemoglobin variants, and is probably the most used material for HPLC of intact proteins; 4) The introduction of ERLIC (2008), a combination of HILIC and electrostatic repulsion which is used for separations in proteomics. Dr. Alpert is the author of over 30 papers and holds 3 patents.