Increasing Throughput for Pharmaceutical and Bioanalytical Methods Using UHPLC

with Jim Grinias
Tuesday, October 16, 2018
Registration Has Ended
About This Meeting

One of today’s most widely used analytical tools is ultra-high pressure liquid chromatography (UHPLC). Compared to traditional HPLC techniques, UHPLC enables higher chromatographic efficiency and reduced method times, but requires two- to four- fold increases in system pressure. With this increased pressure, separation performance can suffer due to viscous friction effects across the length and radius of the column. In this presentation, the impact of thermal broadening on chromatographic performance will be described. Additionally, potential solutions for minimizing efficiency loss based on column selection and the instrument’s thermal settings will be explored. The use of these strategies was employed for two high-throughput UHPLC applications: (1) analysis of neurotransmitters in dialysate samples, and (2) content and impurity analysis in over-the-counter analgesics.

Speakers
Jim Grinias
Rowan University
  • Pricing
    • Registration: Non-Student $30
    • Registration: Student $15
  • Event Times
    • 05:00 PM Executive Committee Meeting
    • 06:00 PM Social Hour
    • 06:30 PM Dinner
    • 07:30 PM Presentation
  • Location
    Spasso Italian Grill
    1 West State Street
    Media, PA 19603
  • Meal Options
    • Sauteed Chicken Marsala In A Mushroom Demi Glaze
    • Grilled Salmon Finished With A Sundried Tomato And Caper Sauce
    • Eggplant Parmesan