Host-Cell Protein Impurities in Chromatographic Purification of Monoclonal Antibodies

with Abraham Lenhoff
Tuesday, June 11, 2024
Registration Has Ended
About This Meeting

 

For protein therapeutics produced using recombinant DNA technology, the many proteins native to the producing (host) cells represent impurities that must be removed. These host-cell proteins (HCPs) have long been monitored collectively but in recent years an additional focus has been on small amounts of individual proteins that can be deleterious to the product or the patient; such HCPs have sometimes been found to persist into the final drug product. This presentation will discuss the mechanisms suspected of causing HCP persistence through individual chromatographic purification steps and ways in which the biophysical interactions in a complex mixture can impact product purity.

 

 

Speakers
Abraham Lenhoff
University of Delaware
  • Pricing
    • Registration: Non-Student $15
    • Registration: Student $7.5
  • Event Times
    • 12:00 AM Executive Committee Meeting
    • 05:30 PM Social Hour
    • 06:15 PM Dinner
    • 06:45 PM Presentation
  • Location
    Wilmington Brew Works
    3129 Miller Rd
    Wilmington, DE 19802
  • Meal Options
    • Pizza, Hoagies, Salad, Soft Drinks; Vegetarian Meal Will Be Included