Senior Scientist, Topical Drug Delivery & DMPK

Senior Scientist, Topical Drug Delivery & DMPK

  • Requisition ID: WD126373
  • Position: Full time
  • Open date: Aug 25, 2017 8:55 PM
  • Functional area: Science and Technology
  • Location: 
    Upper Providence, Pennsylvania
  • Required degrees: Bachelors
  • Experience required: 4 years
  • Relocation: No

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Basic qualifications: 
• For a BSc level: 4-8 years of industry experience in LC-MS/MS method development and validation for analysis of small molecules in biological matrices
• For a MSc level: 2-4 years of industry experience in LC-MS/MS method development and validation for analysis of small molecules in biological matrices
• For a PhD level: 0 to 2 years of industry experience, with combined academic and industry experience in Analytical Chemistry


Preferred qualifications: 
• Hands on experience in Mass Spectrometry, with focus on the LC-MS/MS method development and validation for analysis of small molecules in biological matrices
• Master’s degree in Chemistry, Biochemistry or Pharmaceutical Sciences, with focus in Analytical Chemistry
• High learning agility, has the ability and willingness to deal effectively with first-time situations or changing conditions. 
• Can effectively manage daily and routine situations with limited guidance
• Proficient in and demonstrates highly effective oral and written communication skills
• Prioritizes work to remain focused on objectives in rapidly changing circumstances
• Ability to identify and clarify problems for assigned tasks and implement appropriate solutions.
• Team player and ability to work in a matrix environment.
• Demonstrates the flexibility to manage multiple projects in complex virtual /global environments.
• Track record of delivery against objectives and deliverables.


This role will give you the opportunity to work with in silico, in vitro and in vivo concepts and techniques in the selection of NCE’s and optimization of topical formulations for dermal development. 

This role will give the individual opportunity to be involved in the discovery and development of new drug candidates in Dermatology, with focus on the selection of NCEs and optimization of topical formulations by using in silico, in vitro and in vivo tools. Main responsibilities include study design and execution of in vitro skin penetration studies, LC-MS/MS method development and analysis, development of ex vivo skin models and in vitro assays in collaboration with other groups in Dermatology TAU, and overall involvement in the NCE selection and topical formulation optimization workflows. Additional responsibilities will include data analysis, preparation of reports and presentations to project teams. 

The experiences the successful applicant gains during the role will enable the individual to demonstrate;
• Ability to work effectively with discovery project teams by presenting and discussing technical data
• Ability to rapidly develop a comprehensive scientific knowledge of dermal delivery and topical product development
• Involvement in the refinement of in silico and in vitro models necessary for the selection of NCEs and formulation optimization for dermatological indications

Specific key responsibilities will include;
• Independently develop and assess bioanalytical methods (LC-MS/MS) to support skin penetration studies 
• Coordinate and perform in vitro skin penetration studies 
• Perform sample processing using liquid handlers and general automation equipment
• Perform LC-MS/MS sample preparation and analyses with focus on the quantification of small molecules in skin and plasma matrices; perform basic to mid-level LC and MS troubleshooting
• Prepare technical reports, protocols and presentations 
• Maintain excellent laboratory notebook records on experiments
• Serve on multi-disciplinary project teams as Topical Deliver representative
• Handling of biohazardous materials and chemicals
• Present data in discussion groups and team meetings


Contact information: 
You may apply for this position online by selecting the Apply now button.


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